SHBG is a protein produced in the liver that plays a crucial role in testosterone therapy. Think of it as a transport system—it binds to testosterone and carries it through your bloodstream to where it’s needed. However, when testosterone is bound to SHBG, it’s tightly held and not readily available for your body to use. This is why free testosterone—the portion of testosterone not bound to SHBG—is so important.
Having a healthy level of SHBG is usually a sign of good overall health. It helps maintain balance in your hormone levels. However, if SHBG is too high, it can bind too much testosterone, leaving less free testosterone available and potentially causing symptoms like low energy or reduced libido. On the other hand, if SHBG levels are too low, it can signal other health concerns, like insulin resistance or metabolic issues, which may also affect how testosterone is distributed and used.
Why SHBG matters in TRT
When you’re on testosterone therapy, SHBG levels are monitored to make sure your treatment is working as it should. If SHBG is too high or too low, it can impact how much free testosterone your body has, which is what really affects how you feel. Your doctor may adjust your treatment plan if needed to help you maintain the right balance.
SHBG is a key part of your body’s hormone system. It’s essential for transporting testosterone, but keeping it at the right level is what helps ensure you’re getting the full benefits of your TRT. The goal is to optimise free testosterone, so you feel and function at your best!